Anaphylactic Reaction to High-Dose Methotrexate
نویسندگان
چکیده
منابع مشابه
Anaphylactic reaction to the first dose of subcutaneous methotrexate in JIA: a case report and literature review
Results A 13-years old adolescent girl diagnosed with polyarticular JIA (RF +/ANA-/HLA-B27-) received the first dose of subcutaneous methotrexate in our Day Care centre due to refractoriness to NSAIDs. While she was leaving the building after 10 minutes of medication she developed urticaria, angioedema, shortness of breath and hypoxia (O2 saturation of 85%). After administration of 0.5ml of 1:1...
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Corresponding author: Krzysztof Pałgan MD Department of Allergology, Clinical Immunology and Internal Diseases Nicolaus Copernicus University Collegium Medicum 75 Ujejskiego St 85-168 Bydgoszcz, Poland Phone: +48 52 365 54 16 Fax: +48 52 348 40 76 E-mail: [email protected] Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum of L. Rydygier in Bydgoszcz, Nicolaus C...
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Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer-related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who e...
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Pemetrexed is approved to treat non-small cell lung cancer and has an overall favorable toxicity profile. We describe a 58-year-old man who developped an anaphylactic shock within few minutes from the beginning of pemetrexed perfusion. Pemetrexed was discontinued and the patient's symptoms gradually resolved with administration of symptomatic treatment. Serum tryptase level remained normal and ...
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ژورنال
عنوان ژورنال: Pediatric Hematology and Oncology
سال: 1995
ISSN: 0888-0018,1521-0669
DOI: 10.3109/08880019509029559